Anti-hyperglycemic and Antioxidant Properties of Cassia Auriculata Leaves and Flowers on Alloxan Induced Diabetic Rats

Oxidative stress occurs in diabetic patients and experimental models of diabetes. The present study investigated the effects of leaves and flowers parts of Cassia auriculata ethanolic extract on alloxan induced diabetic rats by measuring fasting blood glucose, lipid peroxidation and liver antioxidant enzymes including superoxide dismutase (SOD), catalase (CAT) and glutathione peroxidase (GPx). Treatment to diabetic rats with oral administration of Cassia auriculata at a dose of 120 mg/kg body weight for 15 days resulted in a significant alterations in comparison with diabetic control group. This results indicating that the underlying mechanism of the plants pharmacological action seems to be independent of insulin secretion. The result of the present study proved that the Cassia auriculata leaves and flowers possess significant anti-diabetic activity along with potent antioxidant potential in diabetic conditions.